Pharmacokinetics of Oral Formulations of Gepotidacin (GSK2140944), a Triazaacenaphthylene Bacterial Type II Topoisomerase Inhibitor, in Healthy Adult and Adolescent Participants

Gepotidacin is a novel, first-in-class triazaacenaphthylene antibiotic that may provide a new treatment option for antibiotic-resistant pathogens. Two pharmacokinetic evaluations of oral gepotidacin are presented: a relative bioavailability study that guided formulation development, followed by an a...

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Detalles Bibliográficos
Autores principales: Barth, Aline, Hossain, Mohammad, Brimhall, Darin B., Perry, Caroline R., Tiffany, Courtney A., Xu, Sherry, Dumont, Etienne F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765319/
https://www.ncbi.nlm.nih.gov/pubmed/34633853
http://dx.doi.org/10.1128/AAC.01263-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765319/
https://www.ncbi.nlm.nih.gov/pubmed/34633853
http://dx.doi.org/10.1128/AAC.01263-21

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