PROTAC targeted protein degraders: the past is prologue

Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. In the 20 years since the concept of a proteolysis-targeting chimera (PROTAC) molec...

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Detalles Bibliográficos
Autores principales: Békés, Miklós, Langley, David R., Crews, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765495/
https://www.ncbi.nlm.nih.gov/pubmed/35042991
http://dx.doi.org/10.1038/s41573-021-00371-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8765495/
https://www.ncbi.nlm.nih.gov/pubmed/35042991
http://dx.doi.org/10.1038/s41573-021-00371-6

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