Reduction of Off-Target Effects of Gapmer Antisense Oligonucleotides by Oligonucleotide Extension

AIM: Antisense oligonucleotide (ASO) has the potential to induce off-target effects by inadvertent binding of ASOs to unintended RNAs that have a sequence similar to the target RNA. In the present study, we focused on the association between oligonucleotide length and off-target effects. Oligonucleo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasuhara, Hidenori, Yoshida, Tokuyuki, Sasaki, Kiyomi, Obika, Satoshi, Inoue, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766371/
https://www.ncbi.nlm.nih.gov/pubmed/34994962
http://dx.doi.org/10.1007/s40291-021-00573-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766371/
https://www.ncbi.nlm.nih.gov/pubmed/34994962
http://dx.doi.org/10.1007/s40291-021-00573-z

Ejemplares similares