Algorithm-aided engineering of aliphatic halogenase WelO5* for the asymmetric late-stage functionalization of soraphens

Late-stage functionalization of natural products offers an elegant route to create novel entities in a relevant biological target space. In this context, enzymes capable of halogenating sp(3) carbons with high stereo- and regiocontrol under benign conditions have attracted particular attention. Enab...

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Detalles Bibliográficos
Autores principales: Büchler, Johannes, Malca, Sumire Honda, Patsch, David, Voss, Moritz, Turner, Nicholas J., Bornscheuer, Uwe T., Allemann, Oliver, Le Chapelain, Camille, Lumbroso, Alexandre, Loiseleur, Olivier, Buller, Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766452/
https://www.ncbi.nlm.nih.gov/pubmed/35042883
http://dx.doi.org/10.1038/s41467-022-27999-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766452/
https://www.ncbi.nlm.nih.gov/pubmed/35042883
http://dx.doi.org/10.1038/s41467-022-27999-1

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