PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity

Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important i...

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Autores principales: Khan, Mohd Moin, Kalim, Ubaid Ullah, Khan, Meraj H., Lahesmaa, Riitta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766794/
https://www.ncbi.nlm.nih.gov/pubmed/35069561
http://dx.doi.org/10.3389/fimmu.2021.786857
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author Khan, Mohd Moin
Kalim, Ubaid Ullah
Khan, Meraj H.
Lahesmaa, Riitta
author_facet Khan, Mohd Moin
Kalim, Ubaid Ullah
Khan, Meraj H.
Lahesmaa, Riitta
author_sort Khan, Mohd Moin
collection PubMed
description Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity.
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spelling pubmed-87667942022-01-20 PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity Khan, Mohd Moin Kalim, Ubaid Ullah Khan, Meraj H. Lahesmaa, Riitta Front Immunol Immunology Protein phosphatase 2A (PP2A) is a highly complex heterotrimeric Ser/Thr phosphatase that regulates many cellular processes. The role of PP2A as a tumor suppressor has been extensively studied and reviewed. However, emerging evidence suggests PP2A constrains inflammatory responses and is important in autoimmune and neuroinflammatory diseases. Here, we reviewed the existing literature on the role of PP2A in T-cell differentiation and autoimmunity. We have also discussed the modulation of PP2A activity by endogenous inhibitors and its small-molecule activators as potential therapeutic approaches against autoimmunity. Frontiers Media S.A. 2022-01-05 /pmc/articles/PMC8766794/ /pubmed/35069561 http://dx.doi.org/10.3389/fimmu.2021.786857 Text en Copyright © 2022 Khan, Kalim, Khan and Lahesmaa https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Khan, Mohd Moin
Kalim, Ubaid Ullah
Khan, Meraj H.
Lahesmaa, Riitta
PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title_full PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title_fullStr PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title_full_unstemmed PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title_short PP2A and Its Inhibitors in Helper T-Cell Differentiation and Autoimmunity
title_sort pp2a and its inhibitors in helper t-cell differentiation and autoimmunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766794/
https://www.ncbi.nlm.nih.gov/pubmed/35069561
http://dx.doi.org/10.3389/fimmu.2021.786857
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