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Integration Analysis of Pharmacokinetics and Metabolomics to Predict Metabolic Phenotype and Drug Exposure of Remdesivir

Remdesivir has displayed pharmacological activity against SARS-CoV-2. However, no pharmacometabolomics (PM) or correlation analysis with pharmacokinetics (PK) was revealed. Rats were intravenously administered remdesivir, and a series of blood samples were collected before and after treatment. Compr...

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Detalles Bibliográficos
Autores principales: Du, Ping, Wang, Guoyong, Hu, Ting, Li, Han, An, Zhuoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8766850/
https://www.ncbi.nlm.nih.gov/pubmed/35069201
http://dx.doi.org/10.3389/fphar.2021.779135