Inhibition of minor intron splicing reduces Na(+) and Ca(2+) channel expression and function in cardiomyocytes

Eukaryotic genomes contain a tiny subset of ‘minor class’ introns with unique sequence elements that require their own splicing machinery. These minor introns are present in certain gene families with specific functions, such as voltage-gated Na(+) and voltage-gated Ca(2+) channels. Removal of minor...

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Detalles Bibliográficos
Autores principales: Montañés-Agudo, Pablo, Casini, Simona, Aufiero, Simona, Ernault, Auriane C., van der Made, Ingeborg, Pinto, Yigal M., Remme, Carol Ann, Creemers, Esther E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767276/
https://www.ncbi.nlm.nih.gov/pubmed/34859816
http://dx.doi.org/10.1242/jcs.259191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767276/
https://www.ncbi.nlm.nih.gov/pubmed/34859816
http://dx.doi.org/10.1242/jcs.259191

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