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Prediction of allosteric sites and signaling: Insights from benchmarking datasets

Allostery is a pervasive mechanism that regulates protein activity through ligand binding at a site different from the orthosteric site. The universality of allosteric regulation complemented by the benefits of highly specific and potentially non-toxic allosteric drugs makes uncovering allosteric si...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Strömich, Léonie, Yaliraki, Sophia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767309/
https://www.ncbi.nlm.nih.gov/pubmed/35079717
http://dx.doi.org/10.1016/j.patter.2021.100408