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Prediction of allosteric sites and signaling: Insights from benchmarking datasets
Allostery is a pervasive mechanism that regulates protein activity through ligand binding at a site different from the orthosteric site. The universality of allosteric regulation complemented by the benefits of highly specific and potentially non-toxic allosteric drugs makes uncovering allosteric si...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767309/ https://www.ncbi.nlm.nih.gov/pubmed/35079717 http://dx.doi.org/10.1016/j.patter.2021.100408 |