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Peptide cyclisation promoted by supramolecular complex formation

Phenol ester activated dipeptides that are reluctant to ring-close have been cyclised with the aid of sterically shielding metallo-porphyrins avoiding unwanted intermolecular reactions. The binding of ZnTPP to the dipyridine-functionalised activating phenolic ester was studied by NMR titrations and...

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Detalles Bibliográficos
Autores principales: Hartendorp, Arnout P. T., de Zwart, Felix J., Bieräugel, Hans, de Bruin, Bas, Reek, Joost N. H., van Maarseveen, Jan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767553/
https://www.ncbi.nlm.nih.gov/pubmed/34935833
http://dx.doi.org/10.1039/d1ob02309h