Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection

Covalent inhibitors targeting the main protease (M(pro), or 3CLpro) of SARS-CoV-2 have shown promise in preclinical investigations. Herein, we report the discovery of two new series of molecules that irreversibly bind to SARS-CoV-2 M(pro). These acrylamide containing molecules were discovered using...

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Detalles Bibliográficos
Autores principales: Ge, Rui, Shen, Zuyuan, Yin, Jian, Chen, Wenhua, Zhang, Qi, An, Yulong, Tang, Dewei, Satz, Alexander L., Su, Wenji, Kuai, Letian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening. 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767972/
https://www.ncbi.nlm.nih.gov/pubmed/35063690
http://dx.doi.org/10.1016/j.slasd.2022.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767972/
https://www.ncbi.nlm.nih.gov/pubmed/35063690
http://dx.doi.org/10.1016/j.slasd.2022.01.001

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