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Discovery of SARS-CoV-2 main protease covalent inhibitors from a DNA-encoded library selection
Covalent inhibitors targeting the main protease (M(pro), or 3CLpro) of SARS-CoV-2 have shown promise in preclinical investigations. Herein, we report the discovery of two new series of molecules that irreversibly bind to SARS-CoV-2 M(pro). These acrylamide containing molecules were discovered using...
Autores principales: | Ge, Rui, Shen, Zuyuan, Yin, Jian, Chen, Wenhua, Zhang, Qi, An, Yulong, Tang, Dewei, Satz, Alexander L., Su, Wenji, Kuai, Letian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Inc. on behalf of Society for Laboratory Automation and Screening.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8767972/ https://www.ncbi.nlm.nih.gov/pubmed/35063690 http://dx.doi.org/10.1016/j.slasd.2022.01.001 |
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