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Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems
After oral administration, a drug’s solubility in intestinal fluid is an important parameter influencing bioavailability and if the value is known it can be applied to estimate multiple biopharmaceutical parameters including the solubility limited absorbable dose. Current in vitro measurements may u...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769049/ https://www.ncbi.nlm.nih.gov/pubmed/34923138 http://dx.doi.org/10.1016/j.ejpb.2021.12.006 |