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Comparative Performance of Genomic Methods for the Detection of Pyrazinamide Resistance and Heteroresistance in Mycobacterium tuberculosis

Pyrazinamide is an important component of both drug-susceptible and drug-resistant tuberculosis treatment regimens. Although approximately 50% of rifampin-resistant isolates are also resistant to pyrazinamide, pyrazinamide susceptibility testing is not routinely performed due to the challenging natu...

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Detalles Bibliográficos
Autores principales: Whitfield, Michael G., Engelthaler, David M., Allender, Christopher, Folkerts, Megan, Heupink, Tim H., Limberis, Jason, Warren, Robin M., Van Rie, Annelies, Metcalfe, John Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8769725/
https://www.ncbi.nlm.nih.gov/pubmed/34757831
http://dx.doi.org/10.1128/JCM.01907-21