Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase

Loading of the eukaryotic replicative helicase onto replication origins involves two MCM hexamers forming a double hexamer (DH) around duplex DNA. During S phase, helicase activation requires MCM phosphorylation by Dbf4-dependent kinase (DDK), comprising Cdc7 and Dbf4. DDK selectively phosphorylates...

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Detalles Bibliográficos
Autores principales: Greiwe, Julia F., Miller, Thomas C. R., Locke, Julia, Martino, Fabrizio, Howell, Steven, Schreiber, Anne, Nans, Andrea, Diffley, John F. X., Costa, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770131/
https://www.ncbi.nlm.nih.gov/pubmed/34963704
http://dx.doi.org/10.1038/s41594-021-00698-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770131/
https://www.ncbi.nlm.nih.gov/pubmed/34963704
http://dx.doi.org/10.1038/s41594-021-00698-z

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