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Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase
Loading of the eukaryotic replicative helicase onto replication origins involves two MCM hexamers forming a double hexamer (DH) around duplex DNA. During S phase, helicase activation requires MCM phosphorylation by Dbf4-dependent kinase (DDK), comprising Cdc7 and Dbf4. DDK selectively phosphorylates...
Autores principales: | Greiwe, Julia F., Miller, Thomas C. R., Locke, Julia, Martino, Fabrizio, Howell, Steven, Schreiber, Anne, Nans, Andrea, Diffley, John F. X., Costa, Alessandro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770131/ https://www.ncbi.nlm.nih.gov/pubmed/34963704 http://dx.doi.org/10.1038/s41594-021-00698-z |
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