Induction of CTH expression in response to amino acid starvation confers resistance to anti-LAT1 therapy in MDA-MB-231 cells

L type amino acid transporter 1 (LAT1) is an attractive molecular target for cancer therapy because of its overexpression in many cancer cells. JPH203, a selective LAT1 inhibitor, causes amino acid deprivation and suppresses cancer cell proliferation. However, several cancer cells showed resistance...

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Detalles Bibliográficos
Autores principales: Yamaga, Takashi, Suehiro, Junichi, Wada, Youichiro, Sakurai, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770514/
https://www.ncbi.nlm.nih.gov/pubmed/35046465
http://dx.doi.org/10.1038/s41598-022-04987-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770514/
https://www.ncbi.nlm.nih.gov/pubmed/35046465
http://dx.doi.org/10.1038/s41598-022-04987-5

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