Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing

BACKGROUND: We previously demonstrated the in vitro killing of AML cells by the combination of the lipid-lowering agent bezafibrate (BEZ) and the contraceptive hormone medroxyprogesterone acetate (MPA). A phase II trial demonstrated in vivo safety and efficacy of BEZ and MPA (BaP) in elderly, relaps...

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Detalles Bibliográficos
Autores principales: Jiang, Yao, Southam, Andrew D., Trova, Sandro, Beke, Flavio, Alhazmi, Bader, Francis, Thomas, Radotra, Anshul, di Maio, Alessandro, Drayson, Mark T., Bunce, Chris M., Khanim, Farhat L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770569/
https://www.ncbi.nlm.nih.gov/pubmed/34686779
http://dx.doi.org/10.1038/s41416-021-01570-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770569/
https://www.ncbi.nlm.nih.gov/pubmed/34686779
http://dx.doi.org/10.1038/s41416-021-01570-z

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