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Diffusion kernel-based predictive modeling of KRAS dependency in KRAS wild type cancer cell lines
Recent progress in clinical development of KRAS inhibitors has raised interest in predicting the tumor dependency on frequently mutated RAS-pathway oncogenes. However, even without such activating mutations, RAS proteins represent core components in signal integration of several membrane-bound kinas...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770632/ https://www.ncbi.nlm.nih.gov/pubmed/35046405 http://dx.doi.org/10.1038/s41540-021-00211-8 |