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Plasma membrane effects of sphingolipid-synthesis inhibition by myriocin in CHO cells: a biophysical and lipidomic study

Suppression of a specific gene effect can be achieved by genetic as well as chemical methods. Each approach may hide unexpected drawbacks, usually in the form of side effects. In the present study, the specific inhibitor myriocin was used to block serine palmitoyltransferase (SPT), the first enzyme...

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Detalles Bibliográficos
Autores principales: Monasterio, Bingen G., Jiménez-Rojo, Noemi, García-Arribas, Aritz B., Riezman, Howard, Goñi, Félix M., Alonso, Alicia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770663/
https://www.ncbi.nlm.nih.gov/pubmed/35046440
http://dx.doi.org/10.1038/s41598-021-04648-z