Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice

Aberrant activation of with-no-lysine kinase (WNK)-STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) kinase signaling in the distal convoluted tubule (DCT) causes unbridled activation of the thiazide-sensitive sodium chloride cotransporter (NCC), leading to familial hyperkalemic hyperten...

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Detalles Bibliográficos
Autores principales: Zapf, Ava M., Grimm, Paul R., Al-Qusairi, Lama, Delpire, Eric, Welling, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770744/
https://www.ncbi.nlm.nih.gov/pubmed/35069250
http://dx.doi.org/10.3389/fphys.2021.787323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770744/
https://www.ncbi.nlm.nih.gov/pubmed/35069250
http://dx.doi.org/10.3389/fphys.2021.787323

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