Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1

Chronic lymphocytic leukemia (CLL) has experienced a clinical revolution—thanks to the discovery of crucial pathogenic mechanisms. CLL is still an incurable disease due to intrinsic or acquired resistance of the leukemic clone. Venetoclax is a Bcl-2 inhibitor with a marked activity in CLL, but emerg...

Descripción completa

Detalles Bibliográficos
Autores principales: Fiorcari, Stefania, Maffei, Rossana, Atene, Claudio Giacinto, Mesini, Nicolò, Maccaferri, Monica, Leonardi, Giovanna, Martinelli, Silvia, Paolini, Ambra, Nasillo, Vincenzo, Debbia, Giulia, Potenza, Leonardo, Luppi, Mario, Marasca, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770925/
https://www.ncbi.nlm.nih.gov/pubmed/35070982
http://dx.doi.org/10.3389/fonc.2021.777587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770925/
https://www.ncbi.nlm.nih.gov/pubmed/35070982
http://dx.doi.org/10.3389/fonc.2021.777587

Ejemplares similares