Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner

The molecular mechanism of the tyrosine kinase inhibitor (TKI) resistant lung adenocarcinoma is currently unclear, and the role of methylated adenosine at the N6 position in the resistance of cancer stem cells (CSCs) therapy is unknown. This study identified a novel and effective strategy to enhance...

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Detalles Bibliográficos
Autores principales: Li, Kai, Gao, Shan, Ma, Lei, Sun, Ye, Peng, Zi-Yang, Wu, Jie, Du, Ning, Ren, Hong, Tang, Shou-Ching, Sun, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770959/
https://www.ncbi.nlm.nih.gov/pubmed/35070958
http://dx.doi.org/10.3389/fonc.2021.731561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8770959/
https://www.ncbi.nlm.nih.gov/pubmed/35070958
http://dx.doi.org/10.3389/fonc.2021.731561

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