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Parental Origin of Gsα Inactivation Differentially Affects Bone Remodeling in a Mouse Model of Albright Hereditary Osteodystrophy

Albright hereditary osteodystrophy (AHO) is caused by heterozygous inactivation of GNAS, a complex locus that encodes the alpha‐stimulatory subunit of heterotrimeric G proteins (Gsα) in addition to NESP55 and XLαs due to alternative first exons. AHO skeletal manifestations include brachydactyly, bra...

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Detalles Bibliográficos
Autores principales: McMullan, Patrick, Maye, Peter, Yang, Qingfen, Rowe, David W., Germain‐Lee, Emily L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771002/
https://www.ncbi.nlm.nih.gov/pubmed/35079678
http://dx.doi.org/10.1002/jbm4.10570