Cargando…

α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer

Background: The cytoskeletal linker protein α-Catulin has been shown to be important for tumor progression in various cancers. However, its role in the regulation of cancer stemness remains unclear. Methods: Phenotypic effects of α-Catulin on the cancer stem cell (CSC)-like properties and metastasis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tung, Chia-Hao, Huang, Meng-Fan, Liang, Chen-Hsien, Wu, Yi-Ying, Wu, Jia-En, Hsu, Cheng-Lung, Chen, Yuh-Ling, Hong, Tse-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771551/ https://www.ncbi.nlm.nih.gov/pubmed/35154481 http://dx.doi.org/10.7150/thno.63627

Ejemplares similares

Emerging Roles of the α-Catenin Family Member α-Catulin in Development, Homeostasis and Cancer Progression
por: Gielata, Mateusz, et al.
Publicado: (2022)

DNA damage induces expression of WWP1 to target ΔNp63α to degradation
por: Chen, Ji, et al.
Publicado: (2017)

A WWP2–PTEN–KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice
por: Fu, Jing, et al.
Publicado: (2022)

WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein
por: Zou, Jianping, et al.
Publicado: (2023)

The emerging role of WWP1 in cancer development and progression
por: Hu, Xiaoli, et al.
Publicado: (2021)

Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation
por: Lu, Xia, et al.
Publicado: (2023)

WWP2 and its association with PTEN in endometrial cancer
por: Clements, Aine E., et al.
Publicado: (2015)

WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis
por: Liao, Chunhua, et al.
Publicado: (2021)

Catulin Based Reporter System to Track and Characterize the Population of Invasive Cancer Cells in the Head and Neck Squamous Cell Carcinoma
por: Karpińska, Kamila, et al.
Publicado: (2021)

WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer Cells
por: Yeung, Benjamin, et al.
Publicado: (2013)

Ubiquitin-specific peptidase 5 facilitates cancer stem cell-like properties in lung cancer by deubiquitinating β-catenin
por: Tung, Chia-Hao, et al.
Publicado: (2023)

Alpha-Catulin Contributes to Drug-Resistance of Melanoma by Activating NF-κB and AP-1
por: Kreiseder, Birgit, et al.
Publicado: (2015)

Catulin reporter marks a heterogeneous population of invasive breast cancer cells with some demonstrating plasticity and participating in vascular mimicry
por: Gielata, Mateusz, et al.
Publicado: (2022)

Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
por: Hsiao, Huey-Wen, et al.
Publicado: (2015)

WWP2 is required for normal cell cycle progression
por: Choi, Byeong Hyeok, et al.
Publicado: (2015)

Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells
por: Yu, Zhenlong, et al.
Publicado: (2016)

An Alpha-Catulin Homologue Controls Neuromuscular Function through Localization of the Dystrophin Complex and BK Channels in Caenorhabditis elegans
por: Abraham, Linu S., et al.
Publicado: (2010)

WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice
por: Fukumoto, Chonji, et al.
Publicado: (2014)

Alpha-Catulin, a New Player in a Rho Dependent Apical Constriction That Contributes to the Mouse Neural Tube Closure
por: Karpińska, Kamila, et al.
Publicado: (2020)

A DNA Aptamer Targeting Galectin-1 as a Novel Immunotherapeutic Strategy for Lung Cancer
por: Tsai, Yao-Tsung, et al.
Publicado: (2019)

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
por: Shi, Peiguo, et al.
Publicado: (2017)

KLF4α stimulates breast cancer cell proliferation by acting as a KLF4 antagonist
por: Ferralli, Jacqueline, et al.
Publicado: (2016)

DNA methylation maintains the CLDN1-EPHB6-SLUG axis to enhance chemotherapeutic efficacy and inhibit lung cancer progression
por: Wu, Jia-En, et al.
Publicado: (2020)

The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia
por: Lu, Xinxin, et al.
Publicado: (2022)

Presynaptic BK channel localization is dependent on the hierarchical organization of alpha-catulin and dystrobrevin and fine-tuned by CaV2 calcium channels
por: Oh, Kelly H, et al.
Publicado: (2015)

Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer
por: Jung, Jin-Gyoung, et al.
Publicado: (2014)

Etomidate inhibits cell proliferation and induces apoptosis in A549 non-small cell lung cancer cells via downregulating WWP2
por: Li, Deqiang, et al.
Publicado: (2021)

WWP2-WWP1 Ubiquitin Ligase Complex Coordinated by PPM1G Maintains the Balance between Cellular p73 and ΔNp73 Levels
por: Chaudhary, Neelam, et al.
Publicado: (2014)

WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway: WWP2 interacted with PDCD4 ameliorates AS
por: Wang, Xingye, et al.
Publicado: (2022)

Dysregulation of the miR‐16‐WWP1 signalling pathway leads to colorectal tumorigenesis
por: Chen, Xiaorui, et al.
Publicado: (2022)

Wwp2 maintains cartilage homeostasis through regulation of Adamts5
por: Mokuda, Sho, et al.
Publicado: (2019)

WWP1 germline variants are associated with normocephalic autism spectrum disorder
por: Novelli, Giuseppe, et al.
Publicado: (2020)

WWP1 Deficiency Alleviates Cardiac Remodeling Induced by Simulated Microgravity
por: Zhong, Guohui, et al.
Publicado: (2021)

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling
por: Chen, Huimei, et al.
Publicado: (2019)

A novel DNA aptamer targeting lung cancer stem cells exerts a therapeutic effect by binding and neutralizing Annexin A2
por: Wu, Yi-Ying, et al.
Publicado: (2022)

Curcumin Promotes KLF5 Proteasome Degradation through Downregulating YAP/TAZ in Bladder Cancer Cells
por: Gao, Yang, et al.
Publicado: (2014)

miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway
por: Huang, Yan, et al.
Publicado: (2021)

Overexpression of WWP1 Promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma
por: Zhang, Xiao-Fei, et al.
Publicado: (2015)

Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled
por: Mund, Thomas, et al.
Publicado: (2015)

Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X
por: You, Shilong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_h2kasf0n4me38mb45k65bg7rln