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The role of mediator subunit 12 in tumorigenesis and cancer therapeutics

Mediator complex subunit 12 (MED12) is a subunit of Mediator, a large multi-subunit protein complex that acts an important regulator of transcription. Specifically, MED12 is an integral part of the kinase module of Mediator along with MED13, CyclinC (CycC) and CDK8. Structural studies have indicated...

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Detalles Bibliográficos
Autores principales: Gonzalez, Cristian G., Akula, Shivani, Burleson, Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771631/
https://www.ncbi.nlm.nih.gov/pubmed/35111243
http://dx.doi.org/10.3892/ol.2022.13194