Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression

[Image: see text] A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and...

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Autores principales: Le, Tu Cam, Pulat, Sultan, Lee, Jihye, Kim, Geum Jin, Kim, Haerin, Lee, Eun-Young, Hillman, Prima F., Choi, Hyukjae, Yang, Inho, Oh, Dong-Chan, Kim, Hangun, Nam, Sang-Jip, Fenical, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771697/
https://www.ncbi.nlm.nih.gov/pubmed/35071867
http://dx.doi.org/10.1021/acsomega.1c04520
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author Le, Tu Cam
Pulat, Sultan
Lee, Jihye
Kim, Geum Jin
Kim, Haerin
Lee, Eun-Young
Hillman, Prima F.
Choi, Hyukjae
Yang, Inho
Oh, Dong-Chan
Kim, Hangun
Nam, Sang-Jip
Fenical, William
author_facet Le, Tu Cam
Pulat, Sultan
Lee, Jihye
Kim, Geum Jin
Kim, Haerin
Lee, Eun-Young
Hillman, Prima F.
Choi, Hyukjae
Yang, Inho
Oh, Dong-Chan
Kim, Hangun
Nam, Sang-Jip
Fenical, William
author_sort Le, Tu Cam
collection PubMed
description [Image: see text] A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in 1 were assigned by using the C(3) Marfey’s analysis and comparing them with those of 2 based on their biosynthetic pathways. Nobilamide I (1) decreased cell motility by inhibiting epithelial–mesenchymal transition markers in A549 (lung cancer), AGS (gastric cancer), and Caco2 (colorectal cancer) cell lines. In addition, 1 modulated the expression of the matrix metalloproteinase (MMP) family (MMP2 and MMP9) in the three cell lines.
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spelling pubmed-87716972022-01-21 Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression Le, Tu Cam Pulat, Sultan Lee, Jihye Kim, Geum Jin Kim, Haerin Lee, Eun-Young Hillman, Prima F. Choi, Hyukjae Yang, Inho Oh, Dong-Chan Kim, Hangun Nam, Sang-Jip Fenical, William ACS Omega [Image: see text] A cyclic depsipeptide, nobilamide I (1), along with the known peptide A-3302-B/TL-119 (2), was isolated from the saline cultivation of the marine-derived bacterium Saccharomonospora sp., strain CNQ-490. The planar structure of 1 was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data. The absolute configurations of the amino acids in 1 were assigned by using the C(3) Marfey’s analysis and comparing them with those of 2 based on their biosynthetic pathways. Nobilamide I (1) decreased cell motility by inhibiting epithelial–mesenchymal transition markers in A549 (lung cancer), AGS (gastric cancer), and Caco2 (colorectal cancer) cell lines. In addition, 1 modulated the expression of the matrix metalloproteinase (MMP) family (MMP2 and MMP9) in the three cell lines. American Chemical Society 2022-01-03 /pmc/articles/PMC8771697/ /pubmed/35071867 http://dx.doi.org/10.1021/acsomega.1c04520 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Le, Tu Cam
Pulat, Sultan
Lee, Jihye
Kim, Geum Jin
Kim, Haerin
Lee, Eun-Young
Hillman, Prima F.
Choi, Hyukjae
Yang, Inho
Oh, Dong-Chan
Kim, Hangun
Nam, Sang-Jip
Fenical, William
Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title_full Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title_fullStr Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title_full_unstemmed Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title_short Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial–Mesenchymal Transition and MMP2/9 Expression
title_sort marine depsipeptide nobilamide i inhibits cancer cell motility and tumorigenicity via suppressing epithelial–mesenchymal transition and mmp2/9 expression
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771697/
https://www.ncbi.nlm.nih.gov/pubmed/35071867
http://dx.doi.org/10.1021/acsomega.1c04520
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