siRNA Seed Region Is Divided into Two Functionally Different Domains in RNA Interference in Response to 2′-OMe Modifications

[Image: see text] In RNA interference (RNAi), small interfering RNA (siRNA) functions to suppress the expression of its target mRNA with perfect sequence complementarity. In a mechanism different from above, siRNA also suppresses unintended mRNAs with partial sequence complementarities, mainly to th...

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Detalles Bibliográficos
Autores principales: Kobayashi, Yoshiaki, Fukuhara, Daiki, Akase, Dai, Aida, Misako, Ui-Tei, Kumiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771963/
https://www.ncbi.nlm.nih.gov/pubmed/35071927
http://dx.doi.org/10.1021/acsomega.1c06455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8771963/
https://www.ncbi.nlm.nih.gov/pubmed/35071927
http://dx.doi.org/10.1021/acsomega.1c06455

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