Cargando…
Mechanisms of flecainide induced negative inotropy: An in silico study
It is imperative to develop better approaches to predict how antiarrhythmic drugs with multiple interactions and targets may alter the overall electrical and/or mechanical function of the heart. Safety Pharmacology studies have provided new insights into the multi-target effects of many different cl...
Autores principales: | Yang, Pei-Chi, Giles, Wayne R., Belardinelli, Luiz, Clancy, Colleen E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772296/ https://www.ncbi.nlm.nih.gov/pubmed/34004185 http://dx.doi.org/10.1016/j.yjmcc.2021.05.007 |
Ejemplares similares
-
A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current
por: Yang, Pei-Chi, et al.
Publicado: (2016) -
Region-specific mechanisms of corticosteroid-mediated inotropy in rat cardiomyocytes
por: Wacker, Caroline, et al.
Publicado: (2020) -
Indicators of haemodynamic instability and left ventricular function in a porcine model of esmolol induced negative inotropy
por: Davies, Simon, et al.
Publicado: (2022) -
Quinidine Effects on Heart Muscle Positive and negative inotropy in relation to depression of the cardiac sarcotubular calcium pump
por: Kennedy, Barbara L.
Publicado: (1969) -
In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias
por: Yang, Pei-Chi, et al.
Publicado: (2012)