Enantioselective Synthesis and Pharmacological Evaluation of Aza-CGP37157–Lipoic Acid Hybrids for the Treatment of Alzheimer’s Disease

Hybrids based on an aza-analogue of CGP37157, a mitochondrial Na(+)/Ca(2+) exchanger antagonist, and lipoic acid were obtained in order to combine in a single molecule the antioxidant and NRF2 induction properties of lipoic acid and the neuroprotective activity of CGP37157. The four possible enantio...

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Detalles Bibliográficos
Autores principales: Cores, Ángel, Michalska, Patrycja, Pérez, José Miguel, Crisman, Enrique, Gómez, Clara, Villacampa, Mercedes, Menéndez, José Carlos, León, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772772/
https://www.ncbi.nlm.nih.gov/pubmed/35052616
http://dx.doi.org/10.3390/antiox11010112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772772/
https://www.ncbi.nlm.nih.gov/pubmed/35052616
http://dx.doi.org/10.3390/antiox11010112

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