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Effect of Different Piperacillin-Tazobactam Dosage Regimens on Synergy of the Combination with Tobramycin against Pseudomonas aeruginosa for the Pharmacokinetics of Critically Ill Patients in a Dynamic Infection Model
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) assessed piperacillin-tazobactam and tobramycin monotherapies and combinations against four isolates over 72 h. A 120 h-dyn...
Autores principales: | Tait, Jessica R., Bilal, Hajira, Rogers, Kate E., Lang, Yinzhi, Kim, Tae-Hwan, Zhou, Jieqiang, Wallis, Steven C., Bulitta, Jürgen B., Kirkpatrick, Carl M. J., Paterson, David L., Lipman, Jeffrey, Bergen, Phillip J., Roberts, Jason A., Nation, Roger L., Landersdorfer, Cornelia B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772788/ https://www.ncbi.nlm.nih.gov/pubmed/35052977 http://dx.doi.org/10.3390/antibiotics11010101 |
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