Cargando…

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens

DNA gyrase and topoisomerase IV are proven to be validated targets in the design of novel antibacterial drugs. In this study, we report the antibacterial evaluation and molecular docking studies of previously synthesized two series of cyclic diphenylphosphonates (1a–e and 2a–e) as DNA gyrase inhibit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saleh, Neveen M., Moemen, Yasmine S., Mohamed, Sara H., Fathy, Ghady, Ahmed, Abdullah A. S., Al-Ghamdi, Ahmed A., Ullah, Sami, El Sayed, Ibrahim El-Tantawy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772930/ https://www.ncbi.nlm.nih.gov/pubmed/35052930 http://dx.doi.org/10.3390/antibiotics11010053

Ejemplares similares

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones
por: Malik, Muhammad, et al.
Publicado: (2016)

Diphenyl (cyclopentylamido)phosphonate
por: Sabbaghi, Fahimeh, et al.
Publicado: (2011)

Diphenyl (o-tolylamido)phosphonate
por: Sabbaghi, Fahimeh, et al.
Publicado: (2011)

Synthesis, Biocidal and Antibiofilm Activities of New Isatin–Quinoline Conjugates against Multidrug-Resistant Bacterial Pathogens along with Their In Silico Screening
por: Elmongy, Elshaymaa I., et al.
Publicado: (2022)

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
por: Parkinson, Elizabeth I., et al.
Publicado: (2015)

Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors
por: Mohammed, Hamada H. H., et al.
Publicado: (2022)

Impact of Amino Acid Substitutions in B Subunit of DNA Gyrase in Mycobacterium leprae on Fluoroquinolone Resistance
por: Yokoyama, Kazumasa, et al.
Publicado: (2012)

AI-based adaptive personalized content presentation and exercises navigation for an effective and engaging E-learning platform
por: Sayed, Wafaa S., et al.
Publicado: (2022)

Dimethyl (1-hydroxy-1,2-diphenylethyl)phosphonate
por: Acar, Nurcan, et al.
Publicado: (2009)

Diethyl (1-hydroxy-1,2-diphenylethyl)phosphonate
por: Acar, Nurcan, et al.
Publicado: (2009)

Dimethyl (1-hydroxy-1,2-diphenylethyl)phosphonate
por: Tahir, M. Nawaz, et al.
Publicado: (2009)

Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design
por: Drlica, Karl, et al.
Publicado: (2014)

Alternations in DNA gyrase genes in low-level fluoroquinolone-resistant Moraxella catarrhalis strains isolated in Poland
por: Król-Turmińska, Katarzyna, et al.
Publicado: (2018)

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
por: Franke, Raimo, et al.
Publicado: (2021)

Design, Synthesis, and Antiproliferative Activity of Novel Neocryptolepine–Rhodanine Hybrids
por: El-Bahnsawye, Mohamed, et al.
Publicado: (2022)

DNA Binding and Cleavage, Stopped-Flow Kinetic, Mechanistic, and Molecular Docking Studies of Cationic Ruthenium(II) Nitrosyl Complexes Containing “NS(4)” Core
por: Shereef, Hadeer A., et al.
Publicado: (2023)

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones
por: Basarab, Gregory S., et al.
Publicado: (2022)

Synthesis, Docking Studies, and In Vitro Evaluation of Some Novel Thienopyridines and Fused Thienopyridine–Quinolines as Antibacterial Agents and DNA Gyrase Inhibitors
por: Mohi El-Deen, Eman M., et al.
Publicado: (2019)

Synthesis, Bioactivity and Molecular Docking of Nereistoxin Derivatives Containing Phosphonate
por: Yan, Qiaoli, et al.
Publicado: (2023)

Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts
por: Jang, Hee Seung, et al.
Publicado: (2016)

Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance
por: Tao, Jun, et al.
Publicado: (2013)

Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium
por: Thapa, Jeewan, et al.
Publicado: (2023)

Synthesis and Molecular Docking Study of Novel Pyrimidine Derivatives against COVID-19
por: Alamshany, Zahra M., et al.
Publicado: (2023)

Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica
por: Rushdy, Abeer Ahmed, et al.
Publicado: (2013)

Genome-wide mapping of fluoroquinolone-stabilized DNA gyrase cleavage sites displays drug specific effects that correlate with bacterial persistence
por: Tang, Juechun, et al.
Publicado: (2023)

Comparative Molecular docking analysis of DNA Gyrase subunit A in Pseudomonas aeruginosaPAO1
por: Gupta, Aman, et al.
Publicado: (2013)

Discovery of Two Brominated Oxindole Alkaloids as Staphylococcal DNA Gyrase and Pyruvate Kinase Inhibitors via Inverse Virtual Screening
por: Sayed, Ahmed M., et al.
Publicado: (2020)

Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity
por: Hassan, Ashraf S., et al.
Publicado: (2020)

Diethyl [benzylamino(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonate
por: Jagadeesan, G., et al.
Publicado: (2011)

Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors
por: Hashem, Heba E., et al.
Publicado: (2020)

Synthesis, characterized, QSAR studies and molecular docking of some phosphonates as COVID-19 inhibitors
por: Gholivand, Khodayar, et al.
Publicado: (2022)

The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant Tuberculosis in Colombian Clinical Isolates
por: Alvarez, N., et al.
Publicado: (2014)

Diethyl [(2-bromoanilino)(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonate
por: Suresh, G., et al.
Publicado: (2012)

Diethyl [(2-chloroanilino)(1,3-diphenyl-1H-pyrazol-4-yl)methyl]phosphonate
por: Suresh, G., et al.
Publicado: (2013)

Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds
por: El Sayed, Ibrahim El-Tantawy, et al.
Publicado: (2022)

A comparative study between surgical cut down and percutaneous closure devices in management of large bore arterial access
por: Mousa, Mohamed Ahmed, et al.
Publicado: (2023)

Corneal plates of fluoroquinolone
por: El Mellaoui, Mohammed, et al.
Publicado: (2014)

Exploring the Staphylococcus aureus Gyrase Complex and Human Topoisomerase: Potential Target for Molecular Docking and Biological Studies with Substituted Polychloroaniline
por: Tomar, Richa, et al.
Publicado: (2023)

Solution structures of DNA-bound gyrase
por: Baker, Nicole M., et al.
Publicado: (2011)

DNA Gyrase as a Target for Quinolones
por: Spencer, Angela C., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_tebq8mpitr2hi3sjlffci1ekcb