A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump

RND family efflux pumps are complex macromolecular machines involved in multidrug resistance by extruding antibiotics from the cell. While structural studies and molecular dynamics simulations have provided insights into the architecture and conformational states of the pumps, the path followed by c...

Descripción completa

Detalles Bibliográficos
Autores principales: Webber, Anya, Ratnaweera, Malitha, Harris, Andrzej, Luisi, Ben F., Ntsogo Enguéné, Véronique Yvette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773123/
https://www.ncbi.nlm.nih.gov/pubmed/35052929
http://dx.doi.org/10.3390/antibiotics11010052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773123/
https://www.ncbi.nlm.nih.gov/pubmed/35052929
http://dx.doi.org/10.3390/antibiotics11010052

Ejemplares similares