Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study

Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of tolerance development to organic...

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Detalles Bibliográficos
Autores principales: Marini, Elisabetta, Giorgis, Marta, Leporati, Marta, Rolando, Barbara, Chegaev, Konstantin, Lazzarato, Loretta, Bertinaria, Massimo, Vincenti, Marco, Di Stilo, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773138/
https://www.ncbi.nlm.nih.gov/pubmed/35052670
http://dx.doi.org/10.3390/antiox11010166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773138/
https://www.ncbi.nlm.nih.gov/pubmed/35052670
http://dx.doi.org/10.3390/antiox11010166

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