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Multitarget Antioxidant NO-Donor Organic Nitrates: A Novel Approach to Overcome Nitrates Tolerance, an Ex Vivo Study
Chronic use of glyceryl trinitrate (GTN) is limited by serious side effects, such as tolerance and endothelial dysfunction of coronary and resistance arteries. Although GTN is used as a drug since more than 130 years, the mechanisms of the vasodilatory effects and of tolerance development to organic...
Autores principales: | Marini, Elisabetta, Giorgis, Marta, Leporati, Marta, Rolando, Barbara, Chegaev, Konstantin, Lazzarato, Loretta, Bertinaria, Massimo, Vincenti, Marco, Di Stilo, Antonella |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773138/ https://www.ncbi.nlm.nih.gov/pubmed/35052670 http://dx.doi.org/10.3390/antiox11010166 |
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