Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress

Diisopropylfluorophosphate (DFP), an organophosphate nerve agent (OPNA), exposure causes status epilepticus (SE) and epileptogenesis. In this study, we tested the protective effects of saracatinib (AZD0530), a Src kinase inhibitor, in mixed-sex or male-only Sprague Dawley rats exposed to 4–5 mg/kg D...

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Detalles Bibliográficos
Autores principales: Gage, Meghan, Putra, Marson, Wachter, Logan, Dishman, Kylie, Gard, Megan, Gomez-Estrada, Crystal, Thippeswamy, Thimmasettappa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773289/
https://www.ncbi.nlm.nih.gov/pubmed/35052568
http://dx.doi.org/10.3390/antiox11010061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773289/
https://www.ncbi.nlm.nih.gov/pubmed/35052568
http://dx.doi.org/10.3390/antiox11010061

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