Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6-mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity

BACKGROUND: Inadequate myelosuppression during maintenance therapy for acute lymphoblastic leukemia (ALL) is associated with an increased risk of relapse. One mechanism is skewed metabolism of 6-mercaptopurine (6MP), a major component of maintenance therapy, which results in preferential formation o...

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Detalles Bibliográficos
Autores principales: Cohen, Gordon, Cooper, Stacy, Sison, Edward Allan, Annesley, Colleen, Bhuiyan, Mariam, Brown, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773437/
https://www.ncbi.nlm.nih.gov/pubmed/32909665
http://dx.doi.org/10.1002/pbc.28360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773437/
https://www.ncbi.nlm.nih.gov/pubmed/32909665
http://dx.doi.org/10.1002/pbc.28360

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