The Anti-Proliferative Effect of PI3K/mTOR and ERK Inhibition in Monolayer and Three-Dimensional Ovarian Cancer Cell Models

SIMPLE SUMMARY: In ovarian cancer patients the PI3K/AKT/mTOR and RAS/RAF/MEK/ERK kinase signaling pathways are frequently dysregulated, making them potential targets of therapeutic inhibitors. In this study, we used four human ovarian cancer cell lines grown in two- and three-dimensional models to i...

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Detalles Bibliográficos
Autores principales: Dunn, Elizabeth, Chitcholtan, Kenny, Sykes, Peter, Garrill, Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773481/
https://www.ncbi.nlm.nih.gov/pubmed/35053555
http://dx.doi.org/10.3390/cancers14020395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773481/
https://www.ncbi.nlm.nih.gov/pubmed/35053555
http://dx.doi.org/10.3390/cancers14020395

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