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ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
SIMPLE SUMMARY: PCNA is an interesting target for cancertreatment due to its essential activities in DNA replication and repair and its recently discovered regulatory roles in cellular signaling. Here, we demonstrate that ATX-101, a peptide targeting PCNA, has antitumor effects as a single agent and...
Autores principales: | Gravina, Giovanni Luca, Colapietro, Alessandro, Mancini, Andrea, Rossetti, Alessandra, Martellucci, Stefano, Ventura, Luca, Di Franco, Martina, Marampon, Francesco, Mattei, Vincenzo, Biordi, Leda Assunta, Otterlei, Marit, Festuccia, Claudio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773508/ https://www.ncbi.nlm.nih.gov/pubmed/35053455 http://dx.doi.org/10.3390/cancers14020289 |
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