Rational Development and Characterization of a Ubiquitin Variant with Selectivity for Ubiquitin C-Terminal Hydrolase L3

There is currently a lack of reliable methods and strategies to probe the deubiquitinating enzyme UCHL3. Current small molecules reported for this purpose display reduced potency and selectivity in cellular assays. To bridge this gap and provide an alternative approach to probe UCHL3, our group has...

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Detalles Bibliográficos
Autores principales: Hewitt, Chad S., Das, Chittaranjan, Flaherty, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773573/
https://www.ncbi.nlm.nih.gov/pubmed/35053210
http://dx.doi.org/10.3390/biom12010062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773573/
https://www.ncbi.nlm.nih.gov/pubmed/35053210
http://dx.doi.org/10.3390/biom12010062

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