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Clinical Significance of the Duality of Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma
SIMPLE SUMMARY: Wnt/β-catenin mutations in HCCs have a dual phenotype. Jekyll phenotype is defined by high HNF4α status which represses EMT, found in well-to-moderately differentiated HCCs with low AFP levels and good prognosis. HNF4α induces the expression of OATP1B3, which can be recognized as hig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773595/ https://www.ncbi.nlm.nih.gov/pubmed/35053606 http://dx.doi.org/10.3390/cancers14020444 |