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Clinical Significance of the Duality of Wnt/β-Catenin Signaling in Human Hepatocellular Carcinoma

SIMPLE SUMMARY: Wnt/β-catenin mutations in HCCs have a dual phenotype. Jekyll phenotype is defined by high HNF4α status which represses EMT, found in well-to-moderately differentiated HCCs with low AFP levels and good prognosis. HNF4α induces the expression of OATP1B3, which can be recognized as hig...

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Detalles Bibliográficos
Autores principales:	Aoki, Tomoko, Nishida, Naoshi, Kudo, Masatoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773595/ https://www.ncbi.nlm.nih.gov/pubmed/35053606 http://dx.doi.org/10.3390/cancers14020444

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