Identification and Functional Analysis of a Novel CTNNB1 Mutation in Pediatric Medulloblastoma

SIMPLE SUMMARY: We have analyzed a panel of 88 pediatric medulloblastoma tumors for exon 3 mutations from the CTNNB1 gene and identified eight missense point-mutations and one in-frame deletion. We describe and functionally characterize a novel CTNNB1 in-frame deletion (c.109-111del, pSer37del, ΔS37...

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Detalles Bibliográficos
Autores principales: Alaña, Lide, Nunes-Xavier, Caroline E., Zaldumbide, Laura, Martin-Guerrero, Idoia, Mosteiro, Lorena, Alba-Pavón, Piedad, Villate, Olatz, García-Obregón, Susana, González-García, Hermenegildo, Herraiz, Raquel, Astigarraga, Itziar, Pulido, Rafael, García-Ariza, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773623/
https://www.ncbi.nlm.nih.gov/pubmed/35053583
http://dx.doi.org/10.3390/cancers14020421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773623/
https://www.ncbi.nlm.nih.gov/pubmed/35053583
http://dx.doi.org/10.3390/cancers14020421

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