MDM2-Driven Ubiquitination Rapidly Removes p53 from Its Cognate Promoters

MDM2 is the principal antagonist of the tumor suppressor p53. p53 binds to its cognate DNA element within promoters and activates the transcription of adjacent genes. These target genes include MDM2. Upon induction by p53, the MDM2 protein binds and ubiquitinates p53, triggering its proteasomal degr...

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Detalles Bibliográficos
Autores principales: Henningsen, Kester Mo, Manzini, Valentina, Magerhans, Anna, Gerber, Sabrina, Dobbelstein, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773640/
https://www.ncbi.nlm.nih.gov/pubmed/35053170
http://dx.doi.org/10.3390/biom12010022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773640/
https://www.ncbi.nlm.nih.gov/pubmed/35053170
http://dx.doi.org/10.3390/biom12010022

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