Cargando…

Effects of Delivering Guanidinoacetic Acid or Its Prodrug to the Neural Tissue: Possible Relevance for Creatine Transporter Deficiency

The creatine precursor guanidinoacetate (GAA) was used as a dietary supplement in humans with no adverse events. Nevertheless, it has been suggested that GAA is epileptogenic or toxic to the nervous system. However, increased GAA content in rodents affected by guanidinoacetate methyltransferase (GAM...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adriano, Enrico, Salis, Annalisa, Damonte, Gianluca, Millo, Enrico, Balestrino, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773658/ https://www.ncbi.nlm.nih.gov/pubmed/35053827 http://dx.doi.org/10.3390/brainsci12010085

Ejemplares similares

Creatine salts provide neuroprotection even after partial impairment of the creatine transporter
por: Adriano, E., et al.
Publicado: (2017)

Lack of Epileptogenic Effects of the Creatine Precursor Guanidinoacetic Acid on Neuronal Cultures In Vitro
por: Poggio, Fabio, et al.
Publicado: (2022)

Processing mechanism of guanidinoacetate in choroid plexus epithelial cells: conversion of guanidinoacetate to creatine via guanidinoacetate N-methyltransferase and monocarboxylate transporter 12-mediated creatine release into the CSF
por: Jomura, Ryuta, et al.
Publicado: (2022)

Creatine as a Candidate to Prevent Statin Myopathy
por: Balestrino, Maurizio, et al.
Publicado: (2019)

Case Series of Creatine Deficiency Syndrome due to Guanidinoacetate Methyltransferase Deficiency
por: Narayan, Vinu, et al.
Publicado: (2020)

Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
por: Neu, Axel, et al.
Publicado: (2020)

Effects of dietary guanidinoacetic acid on growth performance, guanidinoacetic acid absorption and creatine metabolism of lambs
por: Zhang, Shiqi, et al.
Publicado: (2022)

Guanidinoacetic acid in human nutrition: Beyond creatine synthesis
por: Ostojic, Sergej M., et al.
Publicado: (2023)

Guanidinoacetate Methyltransferase (GAMT) Deficiency, A Cerebral Creatine Deficiency Syndrome: A Rare Treatable Metabolic Disorder
por: Yoganathan, Sangeetha, et al.
Publicado: (2020)

Guanidinoacetate–creatine in secondary progressive multiple sclerosis: a case report
por: Ostojic, Sergej M., et al.
Publicado: (2022)

γ-Aminobutyric Acid Transporter 2 Mediates the Hepatic Uptake of Guanidinoacetate, the Creatine Biosynthetic Precursor, in Rats
por: Tachikawa, Masanori, et al.
Publicado: (2012)

Gene therapy for guanidinoacetate methyltransferase deficiency restores cerebral and myocardial creatine while resolving behavioral abnormalities
por: Khoja, Suhail, et al.
Publicado: (2022)

Elicited ROS Scavenging Activity, Photoprotective, and Wound-Healing Properties of Collagen-Derived Peptides from the Marine Sponge Chondrosia reniformis
por: Pozzolini, Marina, et al.
Publicado: (2018)

From broiler breeder hen feed to the egg and embryo: The molecular effects of guanidinoacetate supplementation on creatine transport and synthesis
por: Reicher, Naama, et al.
Publicado: (2020)

Role of Creatine in the Heart: Health and Disease
por: Balestrino, Maurizio
Publicado: (2021)

Fibrinogen αC‐regions are not directly involved in fibrin polymerization as evidenced by a “Double‐Detroit” recombinant fibrinogen mutant and knobs‐mimic peptides
por: Duval, Cédric, et al.
Publicado: (2020)

Novel guanidinoacetate methyltransferase (GAMT) mutation associated with cerebral creatine deficiency syndrome in a Syrian child: a case report
por: Alhomsi, Dima, et al.
Publicado: (2023)

Stability of creatine monohydrate and guanidinoacetic acid during manufacture (retorting and extrusion) and storage of dog foods
por: van der Poel, Antonius F. B., et al.
Publicado: (2019)

Effect of post-ruminal guanidinoacetic acid supplementation on creatine synthesis and plasma homocysteine concentrations in cattle
por: Ardalan, Mehrnaz, et al.
Publicado: (2020)

Effects of supplemental creatine and guanidinoacetic acid on spatial memory and the brain of weaned Yucatan miniature pigs
por: Robinson, Jason L., et al.
Publicado: (2020)

Engineering new metabolic pathways in isolated cells for the degradation of guanidinoacetic acid and simultaneous production of creatine
por: Bianchi, Marzia, et al.
Publicado: (2022)

Guanidinoacetate Is More Effective than Creatine at Enhancing Tissue Creatine Stores while Consequently Limiting Methionine Availability in Yucatan Miniature Pigs
por: McBreairty, Laura E., et al.
Publicado: (2015)

In vitro study of uptake and synthesis of creatine and its precursors by cerebellar granule cells and astrocytes suggests some hypotheses on the physiopathology of the inherited disorders of creatine metabolism
por: Carducci, Claudia, et al.
Publicado: (2012)

Creatine Metabolism and Safety Profiles after Six-Week Oral Guanidinoacetic Acid Administration in Healthy Humans
por: Ostojic, Sergej M., et al.
Publicado: (2013)

Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study
por: Ostojic, Sergej M., et al.
Publicado: (2018)

Journey on VX-809-Based Hybrid Derivatives towards Drug-like F508del-CFTR Correctors: From Molecular Modeling to Chemical Synthesis and Biological Assays
por: Parodi, Alice, et al.
Publicado: (2022)

Guanidinoacetic acid deficiency: a new entity in clinical medicine?
por: Ostojic, Sergej M., et al.
Publicado: (2020)

The Creatine Transporter Unfolded: A Knotty Premise in the Cerebral Creatine Deficiency Syndrome
por: Farr, Clemens V., et al.
Publicado: (2020)

Guanidinoacetic acid supplementation improves feed conversion in broilers subjected to heat stress associated with muscle creatine loading and arginine sparing
por: Majdeddin, M., et al.
Publicado: (2020)

Guanidinoacetate N-methyltransferase deficiency: Case report and brief review of the literature
por: Libell, Joshua L., et al.
Publicado: (2023)

A Bioactive Olive Pomace Extract Prevents the Death of Murine Cortical Neurons Triggered by NMDAR Over-Activation
por: Franchi, Alice, et al.
Publicado: (2020)

A novel mouse model of creatine transporter deficiency
por: Baroncelli, Laura, et al.
Publicado: (2014)

Creatine transporter deficiency: Novel mutations and functional studies
por: Ardon, O., et al.
Publicado: (2016)

Novel translational phenotypes and biomarkers for creatine transporter deficiency
por: Mazziotti, Raffaele, et al.
Publicado: (2020)

Creatine transporter–deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy
por: Duran‐Trio, Lara, et al.
Publicado: (2021)

Combining voltammetric and mass spectrometric data to evaluate iron organic speciation in subsurface coastal seawater samples of the Ross sea (Antarctica)
por: Vivado, Davide, et al.
Publicado: (2022)

AIRE polymorphism, melanoma antigen-specific T cell immunity, and susceptibility to melanoma
por: Conteduca, Giuseppina, et al.
Publicado: (2016)

Cataloguing guanidinoacetic acid content in nutritional supplements
por: Ostojic, Sergej M., et al.
Publicado: (2022)

Effect of SNPs on Creatine Kinase Structure and Function: Identifying Potential Molecular Mechanisms for Possible Creatine Kinase Deficiency Diseases
por: Li, Chang, et al.
Publicado: (2012)

Suppression Effects of Betaine-Enriched Spinach on Hyperhomocysteinemia Induced by Guanidinoacetic Acid and Choline Deficiency in Rats
por: Liu, Yi-Qun, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5nscjfni6smnv7f200sk0dmvs1