Introduction of Mutant GNAQ into Endothelial Cells Induces a Vascular Malformation Phenotype with Therapeutic Response to Imatinib

SIMPLE SUMMARY: Mutations in GNAQ underlie vascular malformations, including Sturge-Weber disease. In order to develop novel therapies for lesions with mutant GNAQ, we introduced mutant GNAQ into MS1 endothelial cells. Mutant GNAQ conferred a novel phenotype of progressive vascular malformations in...

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Detalles Bibliográficos
Autores principales: Sasaki, Maiko, Jung, Yoonhee, North, Paula, Elsey, Justin, Choate, Keith, Toussaint, Michael Andrew, Huang, Christina, Radi, Rakan, Perricone, Adam J., Corces, Victor G., Arbiser, Jack L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773683/
https://www.ncbi.nlm.nih.gov/pubmed/35053574
http://dx.doi.org/10.3390/cancers14020413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773683/
https://www.ncbi.nlm.nih.gov/pubmed/35053574
http://dx.doi.org/10.3390/cancers14020413

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