A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α(V)ß(3) Binder for the Treatment of Multiple Cancer Types

SIMPLE SUMMARY: Many cancer drugs are cytotoxic, which means that they kill cancer cells effectively but are also toxic to normal cells. To overcome this problem, we designed a novel compound, VIP236, which consists of three components. The first part enables the drug to target and bind to a protein...

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Detalles Bibliográficos
Autores principales: Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Kopitz, Charlotte, Heroult, Melanie, Zubov, Dmitry, Willuda, Joerg, Schlange, Thomas, Kahnert, Antje, Wong, Harvey, Izumi, Raquel, Hamdy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773721/
https://www.ncbi.nlm.nih.gov/pubmed/35053556
http://dx.doi.org/10.3390/cancers14020391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773721/
https://www.ncbi.nlm.nih.gov/pubmed/35053556
http://dx.doi.org/10.3390/cancers14020391

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