Combinatorial Virtual Screening Revealed a Novel Scaffold for TNKS Inhibition to Combat Colorectal Cancer

The abnormal Wnt signaling pathway leads to a high expression of β-catenin, which causes several types of cancer, particularly colorectal cancer (CRC). The inhibition of tankyrase (TNKS) activity can reduce cancer cell growth, invasion, and resistance to treatment by blocking the Wnt signaling pathw...

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Detalles Bibliográficos
Autores principales: Chang, Chun-Chun, Pan, Sheng-Feng, Wu, Min-Huang, Cheng, Chun-Tse, Su, Yan-Rui, Jiang, Shinn-Jong, Hsu, Hao-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773749/
https://www.ncbi.nlm.nih.gov/pubmed/35052822
http://dx.doi.org/10.3390/biomedicines10010143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773749/
https://www.ncbi.nlm.nih.gov/pubmed/35052822
http://dx.doi.org/10.3390/biomedicines10010143

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