Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways

In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50% cytotoxic concentrations (CC(50)) in the low micromolar and nanomolar range, particularly in two triple-negative b...

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Detalles Bibliográficos
Autores principales: Gutierrez, Denisse A., Contreras, Lisett, Villanueva, Paulina J., Borrego, Edgar A., Morán-Santibañez, Karla, Hess, Jessica D., DeJesus, Rebecca, Larragoity, Manuel, Betancourt, Ana P., Mohl, Jonathon E., Robles-Escajeda, Elisa, Begum, Khodeza, Roy, Sourav, Kirken, Robert A., Varela-Ramirez, Armando, Aguilera, Renato J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773755/
https://www.ncbi.nlm.nih.gov/pubmed/35053370
http://dx.doi.org/10.3390/cells11020254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773755/
https://www.ncbi.nlm.nih.gov/pubmed/35053370
http://dx.doi.org/10.3390/cells11020254

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