Cargando…

Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways

In this study, we identified a novel pyrazole-based derivative (P3C) that displayed potent cytotoxicity against 27 human cancer cell lines derived from different tissue origins with 50% cytotoxic concentrations (CC(50)) in the low micromolar and nanomolar range, particularly in two triple-negative b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gutierrez, Denisse A., Contreras, Lisett, Villanueva, Paulina J., Borrego, Edgar A., Morán-Santibañez, Karla, Hess, Jessica D., DeJesus, Rebecca, Larragoity, Manuel, Betancourt, Ana P., Mohl, Jonathon E., Robles-Escajeda, Elisa, Begum, Khodeza, Roy, Sourav, Kirken, Robert A., Varela-Ramirez, Armando, Aguilera, Renato J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773755/ https://www.ncbi.nlm.nih.gov/pubmed/35053370 http://dx.doi.org/10.3390/cells11020254

Ejemplares similares

Identification of a Unique Cytotoxic Thieno[2,3-c]Pyrazole Derivative with Potent and Selective Anticancer Effects In Vitro
por: Hess, Jessica D., et al.
Publicado: (2022)

Rapid Shift from SARS-CoV-2 Delta to Omicron Sub-Variants within a Dynamic Southern U.S. Borderplex
por: Robles-Escajeda, Elisa, et al.
Publicado: (2023)

Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis
por: Villanueva, Paulina J., et al.
Publicado: (2018)

The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border
por: Grant, Alice Hernandez, et al.
Publicado: (2021)

The SARS‐CoV‐2 origin dilemma: Zoonotic transfer or laboratory leak?
por: Ruiz‐Medina, Blanca E., et al.
Publicado: (2021)

Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells
por: Robles-Escajeda, Elisa, et al.
Publicado: (2013)

What Makes GPCRs from Different Families Bind to the Same Ligand?
por: Dankwah, Kwabena Owusu, et al.
Publicado: (2022)

GPCR-PEnDB: a database of protein sequences and derived features to facilitate prediction and classification of G protein-coupled receptors
por: Begum, Khodeza, et al.
Publicado: (2020)

Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways
por: Ruiz-Medina, Blanca E., et al.
Publicado: (2019)

The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies
por: Ross, Jeremy A., et al.
Publicado: (2017)

The Many Faces of JAKs and STATs Within the COVID-19 Storm
por: Grant, Alice H., et al.
Publicado: (2021)

Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR)
por: Hartman, Lisa L.R., et al.
Publicado: (2019)

Thermal Bioprinting Causes Ample Alterations of Expression of LUCAT1, IL6, CCL26, and NRN1L Genes and Massive Phosphorylation of Critical Oncogenic Drug Resistance Pathways in Breast Cancer Cells
por: Campbell, Aleli, et al.
Publicado: (2020)

Design, Synthesis and Anticandidal Evaluation of Indazole and Pyrazole Derivatives
por: Rodríguez-Villar, Karen, et al.
Publicado: (2021)

Three novel piperidones exhibit tumor-selective cytotoxicity on leukemia cells via protein degradation and stress-mediated mechanisms
por: Contreras, Lisett, et al.
Publicado: (2021)

JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling
por: Grant, Alice H., et al.
Publicado: (2023)

Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy
por: Farani, Priscila Silva Grijó, et al.
Publicado: (2021)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

PKC-Dependent GlyT1 Ubiquitination Occurs Independent of Phosphorylation: Inespecificity in Lysine Selection for Ubiquitination
por: Barrera, Susana P., et al.
Publicado: (2015)

Differential Expression of Non-Coding RNA Signatures in Thyroid Cancer between Two Ethnic Groups
por: Rood, Kristiana, et al.
Publicado: (2021)

Synthesis and Antifungal Activity of the Derivatives of Novel Pyrazole Carboxamide and Isoxazolol Pyrazole Carboxylate
por: Sun, Jialong, et al.
Publicado: (2015)

New Series of Pyrazoles and Imidazo-Pyrazoles Targeting Different Cancer and Inflammation Pathways
por: Signorello, Maria Grazia, et al.
Publicado: (2021)

Assessing the Antioxidant Properties of Larrea tridentata Extract as a Potential Molecular Therapy against Oxidative Stress
por: Skouta, Rachid, et al.
Publicado: (2018)

Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles
por: Venkateswarlu, Vunnam, et al.
Publicado: (2018)

Agentes bacterianos predominantes en las áreas del hospital general de zona no. 24 del instituto mexicano del seguros social de Poza Rica, Ver.
por: Del Angel Colorado, Lisett
Publicado: (2005)

Larrea tridentata Extract Mitigates Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
por: Morán-Santibañez, Karla, et al.
Publicado: (2019)

Manejo del paciente pediátrico en el estudio radiográfico de la mano
por: Aguilera Santibáñez, Jorge Iván
Publicado: (2004)

Use of activated enol ethers in the synthesis of pyrazoles: reactions with hydrazine and a study of pyrazole tautomerism
por: Tarabová, Denisa, et al.
Publicado: (2014)

Microbiological Screening of 5-Functionalized Pyrazoles for the Future Development of Optimized Pyrazole-Based Delivery Systems
por: Brullo, Chiara, et al.
Publicado: (2022)

Ligand-Directed Metalation of a Gold Pyrazolate Cluster
por: Smith, Ryan A., et al.
Publicado: (2023)

ALTERATION OF THE RESPONSE OF PLATELETS TO SURFACE STIMULI BY PYRAZOLE COMPOUNDS
por: Packham, M. A., et al.
Publicado: (1967)

Un acercamiento al estudio del interés superior del menor desde la perspectiva de su intervención en el nuevo proceso penal adversarial
por: Islas aguilera, Denisse Jaqueline
Publicado: (2013)

Virucidal Activity of Gold Nanoparticles Synthesized by Green Chemistry Using Garlic Extract
por: Meléndez-Villanueva, Mayra A., et al.
Publicado: (2019)

Anti-inflammatory and antimicrobial activities of novel pyrazole analogues
por: Surendra Kumar, R., et al.
Publicado: (2016)

Treatment with benznidazole and pentoxifylline regulates microRNA transcriptomic profile in a murine model of Chagas chronic cardiomyopathy
por: Silva Grijó Farani, Priscila, et al.
Publicado: (2023)

(3,5-Dimethylpyrazol-1-yl)[5-(3,5-dimethylpyrazol-1-ylcarbonyl)-2-thienyl]methanone
por: Guzei, Ilia A., et al.
Publicado: (2009)

Pyrazole Carbohydrazide Derivatives of Pharmaceutical Interest
por: Dias, Luiza Rosaria Sousa, et al.
Publicado: (2012)

Synthesis of Chromone-Related Pyrazole Compounds
por: Santos, Clementina M. M., et al.
Publicado: (2017)

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

Preparation and Physicochemical Characterization of Water-Soluble Pyrazole-Based Nanoparticles by Dendrimer Encapsulation of an Insoluble Bioactive Pyrazole Derivative
por: Alfei, Silvana, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4l1g0am1opggq81qphi5f50h13