Gallic Acid Derivatives Propyl Gallate and Epigallocatechin Gallate Reduce rRNA Transcription via Induction of KDM2A Activation

We previously reported that lysine-demethylase 2A (KDM2A), a Jumonji-C histone demethylase, is activated by gallic acid to reduce H3K36me2 levels in the rRNA gene promoter and consequently inhibit rRNA transcription and cell proliferation in the breast cancer cell line MCF-7. Gallic acid activates A...

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Detalles Bibliográficos
Autores principales: Tanaka, Yuji, Tsuneoka, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773796/
https://www.ncbi.nlm.nih.gov/pubmed/35053178
http://dx.doi.org/10.3390/biom12010030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773796/
https://www.ncbi.nlm.nih.gov/pubmed/35053178
http://dx.doi.org/10.3390/biom12010030

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